TWA 40
Synthetic Biomaterials
The TWA will study and validate synthetic materials to common specifications for biological applications at the cellular and tissue levels. Extra- and intracellular synthetic biologics will be developed and characterised as reference materials to constitute a tool box of functional biological parts and devices. The TWA will assess cell-based and cell-free advanced manufacturing capabilities to formulate reference protocols and technologies for cost-effective biosynthetic platforms. International intercomparisons will be initiated to support the formulation of international standards for biological materials and technologies.
Completed Projects | |
1. | Inter-laboratory study of protein nanoscale filaments as internal standards for high resolution electron microscopy |
2. | Characterisation of a protein filament material as an internal calibrant for diagnostic electron microscopy |
3 | Comparability measurements of antibiotic interactions with bacterial model membranes |
4 | Size and size distribution number of synthetic virus-like particles |
7. | Cross-validation of an integrated, phage-derived platform as an open source reference standard for the diagnosis of SARS-CoV-2 |
Active Projects | |
5. | An intracellular distribution number of virus-like particles per cell |
6. | Comparability in the thermal stability of a protein antibiotic |
8 | Physicochemical profiling of virus-like particles as reference materials for vaccine development and virus particle diagnosis |
9. | Validating biosensor binding kinetics for microorganism antigens |
10. | Quantification of an SI-traceable reference material in cells post-transfection |
More information
Dr. Max Ryadnov (Chair) max.ryadnov@npl.co.uk