TWA 40
Synthetic Biomaterials
The TWA will study and validate synthetic
materials to common specifications for biological applications at the cellular
and tissue levels. Extra- and intracellular synthetic biologics will be
developed and characterised as reference materials to constitute a tool box of
functional biological parts and devices. The TWA will assess cell-based and
cell-free advanced manufacturing capabilities to formulate reference protocols
and technologies for cost-effective biosynthetic platforms. International
intercomparisons will be initiated to support the formulation of international
standards for biological materials and technologies.
| Completed Projects | |
| 1. | Inter-laboratory study of protein nanoscale filaments as internal standards for high resolution electron microscopy |
| 2. | Characterisation of a protein filament material as an internal calibrant for diagnostic electron microscopy |
| 3 | Comparability measurements of antibiotic interactions with bacterial model membranes |
| 4 | Size and size distribution number of synthetic virus-like particles |
| 7. | Cross-validation of an integrated, phage-derived platform as an open source reference standard for the diagnosis of SARS-CoV-2 |
| Active Projects | |
| 5. |  An intracellular distribution number of virus-like particles per
cell |
| 6. | Comparability in the thermal stability of a protein
antibiotic |
| 8 |
Physicochemical profiling of virus-like particles as reference
materials for vaccine development and virus particle diagnosis |
| 9. | Validating biosensor binding kinetics for microorganism antigens
|
| 10. | Quantification of an SI-traceable reference material in cells
post-transfection |
More information
Dr. Max Ryadnov (Chair) max.ryadnov@npl.co.uk